乔纳森·阿比利亚（Jonathan Albilia）DMD，理学硕士1， 卡洛斯·埃雷拉（CarlosHerrera -Vizcaíno）DDS2，希拉里·韦斯勒德（ Hillary Weisleder）BSc3，约瑟夫·乔克伦（ Joseph Choukroun）MD1，莎拉姆·加纳蒂（ Shahram Ghanaati）医学，DMD，博士2

· PMID： 30231809

· DOI： 10.1080 / 08869634.2018.1516183

目的：评估富含液体的血小板纤维蛋白（PRF）在颞下颌关节（TMJ）疼痛和功能障碍患者中的临床价值。

方法： 纳入37例痛苦性内乱（ID）（Wilkes'IV）的48例TMJ。患者每隔2周在上关节间隙内注射1.5-2cc PRF。使用视觉模拟量表记录疼痛和主观功能障碍。使用ANOVA检验进行统计分析。

结果： 48个TMJ中有33个（69％）在第8周以及第3、6和12个月时疼痛明显减轻（响应者）。48个TMJ中有15个（31％）没有改善（无响应）。对液体PRF注射的最佳反应者是ID阶段的Wilkes IV（78.5％）和V（100％），而Wilkes I（0％），II（47％）和III（33％）。发现功能障碍无显着性但明显降低。

结论： 初步发现支持液体PRF在大多数TMJ ID疼痛患者中显示出长期镇痛作用。

关键词： 关节炎；LSCC；TMJ内部混乱；i-PRF; 富含血小板的纤维蛋白 低速离心概念；疼痛; 组织工程。

Liquid platelet-rich fibrin injections as a treatment adjunct for painful temporomandibular joints: preliminary results

Jonathan Albilia DMD, MSc1, Carlos Herrera-Vizcaíno DDS2, Hillary Weisleder BSc3, Joseph Choukroun MD1, Shahram Ghanaati MD, DMD, PhD2

· PMID: 30231809

· DOI: 10.1080/08869634.2018.1516183

Objective:To evaluate the clinical benefits of liquid platelet-rich fibrin (PRF) in patients with temporomandibular joint (TMJ) pain and dysfunction.

Methods: Forty-eight TMJs in 37 patients with painful internal derangement (ID) (Wilkes' I-V) were included. Patients were injected with 1.5-2cc of PRF within the superior joint space at 2-week intervals. Pain and subjective dysfunction were recorded using a visual analog scale. Statistical analyses were done using the ANOVA test.

Results: Thirty-three of 48 TMJs (69%) showed significant reduction in pain at 8 weeks, and at 3, 6, and 12 months (Responders). Fifteen of 48 TMJs (31%) did not improve (Non-responders). The best Responders to liquid PRF injections were ID stages Wilkes' IV (78.5%) and V (100%), compared to Wilkes' I (0%), II (47%), and III (33%). A non-significant, but notable decrease in dysfunction was found.

Conclusion: Preliminary findings support that liquid PRF exhibits long-term analgesic effects in most patients with painful TMJ ID.

Keywords: Arthritis; LSCC; TMJ internal derangement; i-PRF; liquid platelet-rich fibrin; low-speed centrifugation concept; pain; tissue engineering.